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The noticed deficiency of an important accumulation of PHN in brain subsequent the intraventricular administration of (+)-amphetamine plus the formation of considerable amounts of PHN from (+)-POH in Mind tissue in vivo supports the watch which the aromatic hydroxylation of amphetamine pursuing its systemic administration occurs predominantly while in the periphery, Which POH is then transported from the blood-Mind barrier, taken up by noradrenergic neurones in Mind where (+)-POH is transformed during the storage vesicles by dopamine β-hydroxylase to PHN. ^

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